Trials & Tribulations of Liver Transplantation‐ are trials now prohibitive without surrogate endpoints?
نویسندگان
چکیده
منابع مشابه
Biomarkers and surrogate endpoints in clinical trials.
One of the most important considerations in designing clinical trials is the choice of outcome measures. These outcome measures could be clinically meaningful endpoints that are direct measures of how patients feel, function, and survive. Alternatively, indirect measures, such as biomarkers that include physical signs of disease, laboratory measures, and radiological tests, often are considered...
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متن کاملTitle Evaluation of Surrogate Endpoints in Clinical Trials
May 15, 2015 Type Package Title Evaluation of Surrogate Endpoints in Clinical Trials Version 0.1-6 Date 2015-05-14 Author Wim Van der Elst, Ariel Alonso & Geert Molenberghs Maintainer Wim Van der Elst Description In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to m...
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Field trials are the cornerstone in the evaluation of new public health interventions in the developing world. There is a tendency to base the introduction of new public health measures on very few trials. This is understandable given the expense in terms of money and time in mounting these trials and the enthusiasm to do something about the persistently high mortality in many parts of the worl...
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ژورنال
عنوان ژورنال: Liver Transplantation
سال: 2021
ISSN: 1527-6465,1527-6473
DOI: 10.1002/lt.25988